※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ova-0174	ENSOARG00000007733.1	W5PCY7	ACVR1
2		iEKPD-Ova-0388	ENSOARG00000017232.1	W5Q704	ACVR1B
3		iEKPD-Ova-0175	ENSOARG00000007755.1	W5PD09	ACVR1C
4		iEKPD-Ova-0218	ENSOARG00000009841.1	W5PJD6	ACVR2A
5		iEKPD-Ova-0030	ENSOARG00000001408.1	W5NTH8	ACVR2B
6		iEKPD-Ova-0389	ENSOARG00000017242.1	W5Q713	ACVRL1
7		iEKPD-Ova-0378	ENSOARG00000016492.1	W5Q4S1	AMHR2
8		iEKPD-Ova-0014	ENSOARG00000000651.1	W5NR79	BMPR1A
9		iEKPD-Ova-0385	ENSOARG00000017161.1	W5Q6S5	BMPR1B
10		iEKPD-Ova-0400	ENSOARG00000017641.1	W5Q885	BMPR2
11		iEKPD-Ova-0239	ENSOARG00000010971.1	W5PMT5	TGFBR1
12		iEKPD-Ova-0338	ENSOARG00000014726.1	W5PZA8	TGFBR2