※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (13) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pat-0438	ENSPTRG00000040684.2	A0A2I3RIE0
2		iEKPD-Pat-0232	ENSPTRG00000012555.3	A0A2I3SFK9	ACVR1
3		iEKPD-Pat-0082	ENSPTRG00000004964.4	H2Q5Y6	ACVR1B
4		iEKPD-Pat-0231	ENSPTRG00000012554.6	H2QIU8	ACVR1C
5		iEKPD-Pat-0230	ENSPTRG00000012514.6	K7ALD8	ACVR2A
6		iEKPD-Pat-0272	ENSPTRG00000014760.7	A0A2I3SJM1	ACVR2B
7		iEKPD-Pat-0081	ENSPTRG00000004963.7	H2Q5Y5	ACVRL1
8		iEKPD-Pat-0083	ENSPTRG00000005015.6	H2Q624	AMHR2
9		iEKPD-Pat-0050	ENSPTRG00000002706.5	H2Q272	BMPR1A
10		iEKPD-Pat-0306	ENSPTRG00000016293.5	H2QPW8	BMPR1B
11		iEKPD-Pat-0430	ENSPTRG00000029076.5	H2R686	BMPR2
12		iEKPD-Pat-0402	ENSPTRG00000021182.5	A0A2I3S7X1	TGFBR1
13		iEKPD-Pat-0269	ENSPTRG00000014711.6	A0A2I3SE58	TGFBR2