※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pes-0040	ENSPSIG00000003577.1	K7F6W8
2		iEKPD-Pes-0428	ENSPSIG00000018059.1	K7GJF5
3		iEKPD-Pes-0198	ENSPSIG00000009530.1	K7FRC6	ACVR1
4		iEKPD-Pes-0422	ENSPSIG00000017901.1	K7GIW0	ACVR1B
5		iEKPD-Pes-0194	ENSPSIG00000009445.1	K7FR29	ACVR1C
6		iEKPD-Pes-0404	ENSPSIG00000017364.1	K7GH55	ACVR2A
7		iEKPD-Pes-0168	ENSPSIG00000008392.1	K7FMQ7	ACVR2B
8		iEKPD-Pes-0414	ENSPSIG00000017730.1	K7GIE8	ACVRL1
9		iEKPD-Pes-0134	ENSPSIG00000007367.1	K7FJQ9	BMPR1A
10		iEKPD-Pes-0087	ENSPSIG00000005496.1	K7FD41	BMPR1B
11		iEKPD-Pes-0313	ENSPSIG00000013650.1	K7G4Z5	BMPR2
12		iEKPD-Pes-0084	ENSPSIG00000005251.1	K7FC90	TGFBR2