※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (18) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pof-0010	ENSPFOG00000000324.2	A0A087X3H6
2		iEKPD-Pof-0163	ENSPFOG00000006043.2	A0A096M670
3		iEKPD-Pof-0217	ENSPFOG00000007829.2	A0A087XQ44
4		iEKPD-Pof-0221	ENSPFOG00000007986.2	A0A087XQB2
5		iEKPD-Pof-0235	ENSPFOG00000008242.2	A0A087XR96
6		iEKPD-Pof-0262	ENSPFOG00000009167.1	A0A087XTQ2
7		iEKPD-Pof-0376	ENSPFOG00000013261.2	A0A087Y5Q4
8		iEKPD-Pof-0453	ENSPFOG00000015893.2	A0A087YDE8
9		iEKPD-Pof-0472	ENSPFOG00000016327.2	A0A096LRJ0
10		iEKPD-Pof-0481	ENSPFOG00000016625.2	A0A087YFA6
11		iEKPD-Pof-0553	ENSPFOG00000018504.2	A0A087YKR0
12		iEKPD-Pof-0598	ENSPFOG00000019802.2	A0A096MC35
13		iEKPD-Pof-0599	ENSPFOG00000019803.2	A0A087YPH6
14		iEKPD-Pof-0100	ENSPFOG00000003858.2	A0A087XDU1	ACVR1
15		iEKPD-Pof-0105	ENSPFOG00000004103.2	A0A087XE22	ACVR1C
16		iEKPD-Pof-0111	ENSPFOG00000004465.2	A0A087XFP7	ACVR2A
17		iEKPD-Pof-0130	ENSPFOG00000004931.1	A0A087XGQ6	ACVR2B
18		iEKPD-Pof-0122	ENSPFOG00000004667.2	A0A087XG61	BMPR2