※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Poa-0272	ENSPPYG00000012865.2	H2P7L3	ACVR1
2		iEKPD-Poa-0088	ENSPPYG00000004535.2	H2NHC3	ACVR1B
3		iEKPD-Poa-0270	ENSPPYG00000012834.2	H2P7I2	ACVR2A
4		iEKPD-Poa-0303	ENSPPYG00000014006.2	H2PB53	ACVR2B
5		iEKPD-Poa-0087	ENSPPYG00000004534.2	H2NHC1	ACVRL1
6		iEKPD-Poa-0089	ENSPPYG00000004580.1	H2NHH1	AMHR2
7		iEKPD-Poa-0054	ENSPPYG00000002270.2	H2NAD6	BMPR1A
8		iEKPD-Poa-0330	ENSPPYG00000014938.2	H2PDX5	BMPR1B
9		iEKPD-Poa-0283	ENSPPYG00000013085.2	H2P8B8	BMPR2
10		iEKPD-Poa-0271	ENSPPYG00000012864.2	H2P7L2	CR201_G0040103
11		iEKPD-Poa-0431	ENSPPYG00000019439.2	H2PSV9	TGFBR1
12		iEKPD-Poa-0306	ENSPPYG00000014049.2	H2PBA1	TGFBR2