※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (10)  or Unreviewed (3) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ran-0086	ENSRNOG00000005033.6	P80201	Acvr1
2		iEKPD-Ran-0110	ENSRNOG00000006934.7	P80202	Acvr1b
3		iEKPD-Ran-0080	ENSRNOG00000004828.7	P70539	Acvr1c
4		iEKPD-Ran-0091	ENSRNOG00000005334.8	P38444	Acvr2a
5		iEKPD-Ran-0226	ENSRNOG00000014477.7	P38445	Acvr2b
6		iEKPD-Ran-0383	ENSRNOG00000028713.6	P80203	Acvrl1
7		iEKPD-Ran-0233	ENSRNOG00000014850.5	Q62893	Amhr2
8		iEKPD-Ran-0451	ENSRNOG00000052469.1	Q78EA7	Bmpr1a
9		iEKPD-Ran-0115	ENSRNOG00000007036.6	P80204	Tgfbr1
10		iEKPD-Ran-0213	ENSRNOG00000013265.6	P38438	Tgfbr2
11		iEKPD-Ran-0251	ENSRNOG00000016289.7	M0R3J4	Bmpr1b
12		iEKPD-Ran-0346	ENSRNOG00000022196.4	F1LQC5	Bmpr2
13		iEKPD-Ran-0447	ENSRNOG00000050760.2	M0R9M6	LOC103690035