※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sah-0401	ENSSHAG00000017429.1	G3WYP9	ACVR1
2		iEKPD-Sah-0242	ENSSHAG00000012059.1	G3WFA4	ACVR1B
3		iEKPD-Sah-0386	ENSSHAG00000017075.1	G3WXH2	ACVR1C
4		iEKPD-Sah-0192	ENSSHAG00000010152.1	G3W8S1	ACVR2A
5		iEKPD-Sah-0258	ENSSHAG00000012498.1	G3WGT7	ACVR2B
6		iEKPD-Sah-0225	ENSSHAG00000011355.1	G3WCX6	ACVRL1
7		iEKPD-Sah-0018	ENSSHAG00000001044.1	G3VDB6	AMHR2
8		iEKPD-Sah-0091	ENSSHAG00000005672.1	G3VTL3	BMPR1A
9		iEKPD-Sah-0211	ENSSHAG00000010891.1	G3WBC1	BMPR1B
10		iEKPD-Sah-0187	ENSSHAG00000009795.1	G3W7I5	BMPR2
11		iEKPD-Sah-0379	ENSSHAG00000016699.1	G3WW65	TGFBR1
12		iEKPD-Sah-0260	ENSSHAG00000012515.1	G3WGV7	TGFBR2