※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0269	ENSSSCG00000015874.3	A0A287BHU6	ACVR1
2		iEKPD-Sus-0003	ENSSSCG00000000233.4	D3K5N5	ACVR1B
3		iEKPD-Sus-0268	ENSSSCG00000015873.3	F1RPT9	ACVR1C
4		iEKPD-Sus-0265	ENSSSCG00000015669.3	F1S0H6	ACVR2A
5		iEKPD-Sus-0193	ENSSSCG00000011257.3	A0A287BJX6	ACVR2B
6		iEKPD-Sus-0002	ENSSSCG00000000232.4	K7GKU4	ACVRL1
7		iEKPD-Sus-0004	ENSSSCG00000000271.3	F1SFQ8	AMHR2
8		iEKPD-Sus-0170	ENSSSCG00000010360.4	F6Q3D1	BMPR1A
9		iEKPD-Sus-0385	ENSSSCG00000029621.3	K7GKH5	BMPR1B
10		iEKPD-Sus-0275	ENSSSCG00000016113.4	F1SI16	BMPR2
11		iEKPD-Sus-0085	ENSSSCG00000005382.4	K7GSM3	TGFBR1
12		iEKPD-Sus-0190	ENSSSCG00000011226.4	K7GL93	TGFBR2