※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tag-0450	ENSTGUG00000014944.1	H0ZXF6
2		iEKPD-Tag-0361	ENSTGUG00000012182.1	H0ZPM2	ACVR1
3		iEKPD-Tag-0112	ENSTGUG00000003248.1	H0YYI3	ACVR1B
4		iEKPD-Tag-0473	ENSTGUG00000015514.1	H1A2P5	ACVR1C
5		iEKPD-Tag-0354	ENSTGUG00000011916.1	H0ZNV8	ACVR2A
6		iEKPD-Tag-0022	ENSTGUG00000000545.1	H0YQK4	ACVR2B
7		iEKPD-Tag-0113	ENSTGUG00000003267.1	H0YYJ6	ACVRL1
8		iEKPD-Tag-0182	ENSTGUG00000005714.1	H0Z5P5	BMPR1A
9		iEKPD-Tag-0109	ENSTGUG00000003164.1	H0YYB9	BMPR1B
10		iEKPD-Tag-0302	ENSTGUG00000010107.1	H0ZIM1	BMPR2
11		iEKPD-Tag-0134	ENSTGUG00000003987.1	H0Z0M2	LOC100224677
12		iEKPD-Tag-0218	ENSTGUG00000006726.1	H0Z8N4	TGFBR1
13		iEKPD-Tag-0121	ENSTGUG00000003590.1	H0YZF5	TGFBR2