※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ten-0038	ENSTNIG00000002103.1
2		iEKPD-Ten-0044	ENSTNIG00000002260.1	H3C903
3		iEKPD-Ten-0167	ENSTNIG00000006473.1	H3CLW2
4		iEKPD-Ten-0273	ENSTNIG00000009054.1	H3CUH8
5		iEKPD-Ten-0410	ENSTNIG00000013820.1	H3D8I2
6		iEKPD-Ten-0439	ENSTNIG00000014589.1	H3DAS5
7		iEKPD-Ten-0463	ENSTNIG00000015071.1	H3DC81
8		iEKPD-Ten-0493	ENSTNIG00000015803.1	H3DEE2
9		iEKPD-Ten-0541	ENSTNIG00000017166.1	H3DIF9
10		iEKPD-Ten-0583	ENSTNIG00000018688.1	H3DMW8
11		iEKPD-Ten-0591	ENSTNIG00000018951.1	H3DNP0
12		iEKPD-Ten-0615	ENSTNIG00000019387.1	H3DPZ2
13		iEKPD-Ten-0518	ENSTNIG00000016489.1	H3DGE4	ACVR1
14		iEKPD-Ten-0517	ENSTNIG00000016488.1	H3DGE3	ACVR1C
15		iEKPD-Ten-0452	ENSTNIG00000014872.1	H3DBM1	ACVR2B
16		iEKPD-Ten-0388	ENSTNIG00000013283.1	H3D6Y2	BMPR2
17		iEKPD-Ten-0029	ENSTNIG00000001859.1	H3C7L1	TGFBR1 (1 of many)