※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519

  Reviewed (8)  or Unreviewed (3) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Art-1217	AT1G22300	P48347	GRF10; At1g22300; T16E15.8
2		iEKPD-Art-1218	AT1G34760	Q9S9Z8	GRF11; At1g34760; F21H2.3
3		iEKPD-Art-1213	AT1G78300	Q01525	GRF2; GF14; At1g78300; F3F9.16
4		iEKPD-Art-1210	AT5G38480	P42644	GRF3; RCI1A; At5g38480; MXI10.21
5		iEKPD-Art-f001	AT1G35160	P46077	GRF4; At1g35160; T32G9.30
6		iEKPD-Art-1215	AT5G16050	P42645	GRF5; At5g16050; F1N13_190
7		iEKPD-Art-1216	AT5G10450	P48349	GRF6; AFT1; RCI2; At5g10450; F12B17_200
8		iEKPD-Art-1214	AT3G02520	Q96300	GRF7; At3g02520; F16B3.15
9		iEKPD-Art-1212	AT1G35160	F4HWQ5	GF14 PHI; 14-3-3PHI; GENERAL REGULATORY FACTOR 4; GF14 protein phi chain; GRF4; At1g35160; T32G9.30; T32G9_30
10		iEKPD-Art-1211	AT4G09000	F4JJ94	GRF1; general regulatory factor 1; GF14 CHI; At4g09000
11		iEKPD-Art-1219	AT5G65430	F4KHY7	GRF8; 14-3-3KAPPA; general regulatory factor 8; GF14 KAPPA; GF14 KAPPA ISOFORM; MNA5.16; MNA5_16; At5g65430