Chlorocebus sabaeus      (pS/pT)/14-3-3


※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Chs-0633
ENSCSAG00000012007.1
A0A0D9RHV9
2
iEKPD-Chs-0636
ENSCSAG00000000649.1
A0A0D9S918
SFN
3
iEKPD-Chs-0632
ENSCSAG00000014209.1
A0A0D9RP06
YWHAB
4
iEKPD-Chs-0631
ENSCSAG00000014074.1
A0A0D9RNM2
YWHAE
5
iEKPD-Chs-0634
ENSCSAG00000018132.1
A0A0D9RZW1
YWHAG
6
iEKPD-Chs-0635
ENSCSAG00000008504.1
A0A0D9R827
YWHAH