Danio rerio      (pS/pT)/14-3-3


※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519


There are 9 genes.  Reviewed (3 or Unreviewed (6

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Dar-1208
ENSDARG00000013078.9
Q5PRD0
ywhaba; ywhab1; wu:fb80c08
2
iEKPD-Dar-1209
ENSDARG00000075758.3
Q7T356
ywhabb; ywhab; ywhab2; zgc:64092
3
iEKPD-Dar-1213
ENSDARG00000067626.3
Q6PC29
ywhag1; ywhag; zgc:73131
4
iEKPD-Dar-1211
ENSDARG00000040287.7
Q6P102
ywhabl
5
iEKPD-Dar-1205
ENSDARG00000006399.7
Q7ZW20
ywhae1
6
iEKPD-Dar-1206
ENSDARG00000017014.8
Q5CZQ1
ywhae2
7
iEKPD-Dar-1212
ENSDARG00000071658.4
E7F354
ywhag2
8
iEKPD-Dar-1210
ENSDARG00000042539.3
Q7ZUM0
ywhaqa; ywhaq2
9
iEKPD-Dar-1207
ENSDARG00000023323.6
Q803M8
ywhaqb; ywhaq1; ywhaz