※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0641	ENSMICG00000034946.2
2		iEKPD-Mim-0642	ENSMICG00000003595.3
3		iEKPD-Mim-0643	ENSMICG00000037501.2
4		iEKPD-Mim-0644	ENSMICG00000000973.3
5		iEKPD-Mim-0645	ENSMICG00000032559.2
6		iEKPD-Mim-0646	ENSMICG00000012837.3
7		iEKPD-Mim-0647	ENSMICG00000004789.3