※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519

  Reviewed (0)  or Unreviewed (5) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sei-1518	Si002635m.g	K3XL64	LOC101754220; SETIT_002635mg
2		iEKPD-Sei-1519	Si014314m.g	K3YJ95	LOC101760336; SETIT_014314mg
3		iEKPD-Sei-1517	Si020196m.g	K3Z0X9	LOC101776649; SETIT_020196mg
4		iEKPD-Sei-1520	Si014320m.g	K3YJA1	LOC101782608; SETIT_014320mg
5		iEKPD-Sei-1516	Si010865m.g	K3Y9H3	LOC101782762; SETIT_010865mg