※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519

  Reviewed (0)  or Unreviewed (4) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sob-1444	SORBI_3005G145201	A0A1Z5RIM0	SORBI_3005G145201
2		iEKPD-Sob-1441	SORBI_3006G108400	C5Y9W4	SORBI_3006G108400
3		iEKPD-Sob-1442	SORBI_3007G134000	A0A1B6PHN8	SORBI_3007G134000
4		iEKPD-Sob-1443	SORBI_3007G186800	C5YHK9	SORBI_3007G186800