※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519

  Reviewed (0)  or Unreviewed (6) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0653	ENSSSCG00000007381.3	F1SDR7	YWHAB
2		iEKPD-Sus-0652	ENSSSCG00000038989.1	A0A287A2R9	YWHAE
3		iEKPD-Sus-0655	ENSSSCG00000007692.3	F2Z4Z1	YWHAG
4		iEKPD-Sus-0656	ENSSSCG00000010035.3	F2Z4Y1	YWHAH
5		iEKPD-Sus-0654	ENSSSCG00000008638.3	F1SA98	YWHAQ
6		iEKPD-Sus-0651	ENSSSCG00000006062.3	F2Z558	YWHAZ