※ 14-3-3 family introduction

    14-3-3 proteins constitute a highly conserved family of homo- and heterodimeric molecules present in high abundance in eukaryotic cells. The proteins of 14-3-3 family mediate signal transduction by binding to phosphoserine-containing proteins. Through interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle . 14-3-3 interacts with BAD preventing apoptosis by releasing Bcl-XL . In addition, 14-3-3 proteins interact with other signaling molecules including members of the protein kinase C family , Cbl , IRS1 , and polyoma middle-T antigen (1).

Reference
1. Yaffe, M.B., Rittinger, K. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-71. PMID: 9428519

  Reviewed (0)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tra-5262	TRIAE_CS42_2AL_TGACv1_097132_AA0323110	A0A096UL77
2		iEKPD-Tra-5263	TRIAE_CS42_2BL_TGACv1_129320_AA0378530	G5DFC5
3		iEKPD-Tra-5265	TRIAE_CS42_3B_TGACv1_228257_AA0826370	A0A1D5WBE1
4		iEKPD-Tra-5266	TRIAE_CS42_3AS_TGACv1_210940_AA0681760	W5CLK1
5		iEKPD-Tra-5264	TRIAE_CS42_3DS_TGACv1_271450_AA0898660	L0GDQ5	14R1
6		iEKPD-Tra-5267	TRIAE_CS42_4AL_TGACv1_289949_AA0979320	L0GED8	14R2; 4333880 (1 of many)
7		iEKPD-Tra-5268	TRIAE_CS42_4DL_TGACv1_342693_AA1119840	A0A1D5XX39	4350697 (1 of many)
8		iEKPD-Tra-5269	TRIAE_CS42_4BS_TGACv1_328071_AA1082280	Q9FXQ9	TaWIN1; 4350697 (1 of many)