※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (1)  or Unreviewed (8) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Aso-0197	AO090120000322	Q2U6A1	lig4; AO090120000322
2		iEKPD-Aso-0201	AO090001000518	Q2UN38	AO090001000518
3		iEKPD-Aso-0199	AO090003000350	Q2ULM4	AO090003000350
4		iEKPD-Aso-0336	AO090003000695	Q2UKS3	AO090003000695
5		iEKPD-Aso-0195	AO090009000432	Q2UU70	AO090009000432
6		iEKPD-Aso-0202	AO090011000911	Q2TZC5	AO090011000911
7		iEKPD-Aso-0198	AO090102000605	Q2U9Z5	AO090102000605
8		iEKPD-Aso-0200	AO090120000136	Q2U6Q6	AO090120000136
9		iEKPD-Aso-0196	AO090120000483	Q2U5W5	AO090120000483