※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Blg-0162	BGHDH14_bgh01724	N1JR27	BGHDH14_bgh01724
2		iEKPD-Blg-0159	BGHDH14_bgh02333	N1JBZ0	BGHDH14_bgh02333
3		iEKPD-Blg-0163	BGHDH14_bgh04782	N1JED2	BGHDH14_bgh04782
4		iEKPD-Blg-0160	BGHDH14_bgh04820	N1J736	BGHDH14_bgh04820
5		iEKPD-Blg-0164	BGHDH14_bgh06350	N1JEK2	BGHDH14_bgh06350
6		iEKPD-Blg-0161	BGHDH14_bgh06656	N1JGH1	BGHDH14_bgh06656
7		iEKPD-Blg-0270	BGHDH14_bghG001669000002001	N1J6N1	BGHDH14_bghG001669000002001