Bos taurus      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 16 genes.  Reviewed (0 or Unreviewed (16

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Bot-0651
ENSBTAG00000033690.3
F1MAV4
BARD1
2
iEKPD-Bot-0654
ENSBTAG00000022520.4
F1MYX8
BRCA1
3
iEKPD-Bot-0652
ENSBTAG00000023814.4
F1MJ58
ECT2
4
iEKPD-Bot-0655
ENSBTAG00000015868.4
F1MB07
LIG4
5
iEKPD-Bot-0653
ENSBTAG00000011032.5
F1MFA9
MCPH1
6
iEKPD-Bot-0656
ENSBTAG00000025526.4
E1BI26
MDC1
7
iEKPD-Bot-1279
ENSBTAG00000013225.4
F6PSE2
NBN
8
iEKPD-Bot-0658
ENSBTAG00000000837.4
F1MU08
PARP1
9
iEKPD-Bot-0657
ENSBTAG00000025400.4
E1BD73
PARP4
10
iEKPD-Bot-0648
ENSBTAG00000017505.5
G3MZP9
PAXIP1
11
iEKPD-Bot-0660
ENSBTAG00000003576.5
E1BHH1
POLL
12
iEKPD-Bot-0661
ENSBTAG00000043999.2
F1N787
REV1
13
iEKPD-Bot-0659
ENSBTAG00000006107.5
F1MM85
SLF1
14
iEKPD-Bot-0647
ENSBTAG00000000526.5
G3X684
TOPBP1
15
iEKPD-Bot-0649
ENSBTAG00000021304.4
E1BDS6
TP53BP1
16
iEKPD-Bot-0650
ENSBTAG00000016268.5
F1N2F9
XRCC1