※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (13) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Coo-0309	Cob_00043	N4VJM4	Cob_00043
2		iEKPD-Coo-0190	Cob_00417	N4VUQ9	Cob_00417
3		iEKPD-Coo-0192	Cob_04105	N4VIM7	Cob_04105
4		iEKPD-Coo-0189	Cob_04288	N4VU57	Cob_04288
5		iEKPD-Coo-0184	Cob_04893	N4VHY8	Cob_04893
6		iEKPD-Coo-0186	Cob_05219	N4VVB1	Cob_05219
7		iEKPD-Coo-0182	Cob_05445	N4VH92	Cob_05445
8		iEKPD-Coo-0185	Cob_08699	N4V4H5	Cob_08699
9		iEKPD-Coo-0183	Cob_08878	N4V358	Cob_08878
10		iEKPD-Coo-0188	Cob_09445	N4V313	Cob_09445
11		iEKPD-Coo-0181	Cob_09917	N4VGU8	Cob_09917
12		iEKPD-Coo-0187	Cob_12072	N4UTU9	Cob_12072
13		iEKPD-Coo-0191	Cob_07282	N4VAM8	NOP7; Cob_07282