※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (2)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Crn-0147	CNK00930	P0CN08	LIG4; CNK00930
2		iEKPD-Crn-0148	CNB01260	P0CP58	NOP7; CNB01260
3		iEKPD-Crn-0151	CNA01660	Q5KPS9	CNA01660
4		iEKPD-Crn-0146	CNB01590	Q5KMI4	CNB01590
5		iEKPD-Crn-0150	CND04680	Q5KI03	CND04680
6		iEKPD-Crn-0149	CNG04440	Q5KDC9	CNG04440
7		iEKPD-Crn-0152	CNI02280	Q5KBK0	CNI02280
8		iEKPD-Crn-0273	CNI04270	Q5KB01	CNI04270
9		iEKPD-Crn-0153	CNK02520	Q5K9B5	CNK02520