Danio rerio      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 18 genes.  Reviewed (3 or Unreviewed (15

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Dar-2040
ENSDARG00000040303.7
Q5I2W8
nbn; nbs1; zgc:194152
2
iEKPD-Dar-1224
ENSDARG00000005606.9
Q5XIY8
paxip1; zgc:92593
3
iEKPD-Dar-1238
ENSDARG00000018902.6
P79741
pes; si:dkeyp-86g2.3
4
iEKPD-Dar-1230
ENSDARG00000076733.4
B0UZD1
bard1
5
iEKPD-Dar-2025
ENSDARG00000017522.11
E7FFL3
ctdp1
6
iEKPD-Dar-1228
ENSDARG00000007278.9
A0A0R4IKD5
ect2
7
iEKPD-Dar-1231
ENSDARG00000060620.4
F1Q9E8
lig4
8
iEKPD-Dar-1225
ENSDARG00000058372.7
F8W5H6
mcph1
9
iEKPD-Dar-1229
ENSDARG00000086764.3
E7FA74
mdc1; im:7163673
10
iEKPD-Dar-1237
ENSDARG00000019529.8
Q5RHR0
parp1
11
iEKPD-Dar-1234
ENSDARG00000069934.6
F1QHW9
parp4
12
iEKPD-Dar-1233
ENSDARG00000039613.6
B8JIE9
poll
13
iEKPD-Dar-1236
ENSDARG00000018296.10
A0A0R4ISU0
rev1
14
iEKPD-Dar-1235
ENSDARG00000054799.9
F1Q5P6
rfc1
15
iEKPD-Dar-1232
ENSDARG00000102118.1
A0A0R4INB3
slf1; si:ch73-280o22.1
16
iEKPD-Dar-1223
ENSDARG00000059322.7
F1R135
topbp1
17
iEKPD-Dar-1227
ENSDARG00000079000.4
E7F2M6
tp53bp1
18
iEKPD-Dar-1226
ENSDARG00000009494.8
A0A0R4IBN8
xrcc1