※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Dos-0183	DOTSEDRAFT_107780	N1Q2S8	DOTSEDRAFT_107780
2		iEKPD-Dos-0182	DOTSEDRAFT_154628	N1PKL2	DOTSEDRAFT_154628
3		iEKPD-Dos-0180	DOTSEDRAFT_174773	N1PIP1	DOTSEDRAFT_174773
4		iEKPD-Dos-0177	DOTSEDRAFT_19972	N1Q472	DOTSEDRAFT_19972
5		iEKPD-Dos-0184	DOTSEDRAFT_40097	N1Q0K8	DOTSEDRAFT_40097
6		iEKPD-Dos-0178	DOTSEDRAFT_60502	N1PYV5	DOTSEDRAFT_60502
7		iEKPD-Dos-0176	DOTSEDRAFT_68347	N1Q1B5	DOTSEDRAFT_68347
8		iEKPD-Dos-0310	DOTSEDRAFT_73343	N1PM96	DOTSEDRAFT_73343
9		iEKPD-Dos-0179	DOTSEDRAFT_76346	N1Q2F7	DOTSEDRAFT_76346
10		iEKPD-Dos-0175	DOTSEDRAFT_77681	N1PVF3	DOTSEDRAFT_77681
11		iEKPD-Dos-0181	DOTSEDRAFT_80971	M2WNT4	DOTSEDRAFT_80971