Drosophila melanogaster      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 12 genes.  Reviewed (2 or Unreviewed (10

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Drm-0336
FBgn0032138
Q9VL96
CG4364
2
iEKPD-Drm-0334
FBgn0004913
P35600
Gnf1; CG1119
3
iEKPD-Drm-0332
FBgn0030506
Q9VYA5
DNAlig4; DmelCG12176; Lig4; lig4; Lig4-RA; ligaseIV; ligIV; RE37186; CG12176; Dmel_CG12176
4
iEKPD-Drm-0627
FBgn0035026
Q9W147
Fcp1; CG12252; Dmel_CG12252
5
iEKPD-Drm-0328
FBgn0260959
E1JH39
MCPH1; CG42572; Dmel_CG42572
6
iEKPD-Drm-0335
FBgn0002872
Q95RC8
mu2; cDNA D; DmelCG1960; MDC1; Mdc1; mu-2; MU2; Mu2; mutator[2]; CG1960; Dmel_CG1960
7
iEKPD-Drm-0326
FBgn0002878
Q9VY97
mus101; anon-WO0148202.1; DmelCG11156; DmMus101; fs(1)K451; mus 101; mus(1)101; mus-101; Mus101; TOPBP1; CG11156; Dmel_CG11156
8
iEKPD-Drm-0333
FBgn0261530
Q9VT40
nbs; 6754; DmelCG6754; Dnbs1; l(3)67BDp; l(3)67BDr; l(3)e77A1; NBS; Nbs; NBS1; Nbs1; CG6754; Dmel_CG6754
9
iEKPD-Drm-0330
FBgn0003041
Q8IQ97
pbl; 0083; 0293; 03; 0542; 09; 20; anon-WO0172774.22; anon-WO0172774.25; DmelCG8114; Ect-2; ECT2; Ect2; GEF; l(3)09645; PBL; Pbl; CG8114; Dmel_CG8114
10
iEKPD-Drm-0327
FBgn0052133
Q9VUB7
Ptip; CG6532; CG8797; DmelCG32133; PTIP; ptip; CG32133; Dmel_CG32133
11
iEKPD-Drm-0331
FBgn0035150
Q9W0P2
Rev1; AAF47401; DmelCG12189; DmREV1; DmRev1; dREV1; dRev1; drev1; REV1; rev1; CG12189; Dmel_CG12189
12
iEKPD-Drm-0329
FBgn0026751
Q9Y095
XRCC1; 4208; DmelCG4208; Xrcc1; XRCC1-RA; CG4208; Dmel_CG4208