※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Gas-0205	GGTG_00795	J3NHQ8	GGTG_00795
2		iEKPD-Gas-0203	GGTG_01028	J3NIE7	GGTG_01028
3		iEKPD-Gas-0200	GGTG_01034	J3NIF3	GGTG_01034
4		iEKPD-Gas-0198	GGTG_01178	J3NIU4	GGTG_01178
5		iEKPD-Gas-0206	GGTG_01404	J3NJH2	GGTG_01404
6		iEKPD-Gas-0354	GGTG_05336	J3NVM1	GGTG_05336
7		iEKPD-Gas-0199	GGTG_06907	J3P060	GGTG_06907
8		iEKPD-Gas-0201	GGTG_06972	J3P0C5	GGTG_06972
9		iEKPD-Gas-0202	GGTG_07304	J3P1A7	GGTG_07304
10		iEKPD-Gas-0207	GGTG_11301	J3PCT3	GGTG_11301
11		iEKPD-Gas-0204	GGTG_11651	J3PDS8	GGTG_11651