Homo sapiens      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 22 genes.  Reviewed (20 or Unreviewed (2

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Hos-0647
ENSG00000138376.10
Q99728
BARD1
2
iEKPD-Hos-0650
ENSG00000012048.20
P38398
BRCA1; RNF53
3
iEKPD-Hos-1314
ENSG00000060069.16
Q9Y5B0
CTDP1; FCP1
4
iEKPD-Hos-0648
ENSG00000114346.13
Q9H8V3
ECT2
5
iEKPD-Hos-0656
ENSG00000005156.11
P49916
LIG3
6
iEKPD-Hos-0649
ENSG00000174405.13
P49917
LIG4
7
iEKPD-Hos-0646
ENSG00000147316.12
Q8NEM0
MCPH1
8
iEKPD-Hos-1322
ENSG00000137337.14
Q14676
MDC1; KIAA0170; NFBD1
9
iEKPD-Hos-1325
ENSG00000104320.13
O60934
NBN; NBS; NBS1; P95
10
iEKPD-Hos-0655
ENSG00000143799.12
P09874
PARP1; ADPRT; PPOL
11
iEKPD-Hos-0651
ENSG00000102699.5
Q9UKK3
PARP4; ADPRTL1; KIAA0177; PARPL
12
iEKPD-Hos-0643
ENSG00000157212.18
Q6ZW49
PAXIP1; PAXIP1L; PTIP; CAGF28
13
iEKPD-Hos-0657
ENSG00000100029.17
O00541
PES1
14
iEKPD-Hos-0658
ENSG00000166169.16
Q9UGP5
POLL
15
iEKPD-Hos-0654
ENSG00000135945.9
Q9UBZ9
REV1; REV1L
16
iEKPD-Hos-0653
ENSG00000035928.15
P35251
RFC1; RFC140
17
iEKPD-Hos-0652
ENSG00000133302.12
Q9BQI6
SLF1; ANKRD32; BRCTD1
18
iEKPD-Hos-0642
ENSG00000163781.12
Q92547
TOPBP1; KIAA0259
19
iEKPD-Hos-0644
ENSG00000067369.13
Q12888
TP53BP1
20
iEKPD-Hos-0645
ENSG00000073050.11
P18887
XRCC1
21
iEKPD-Hos-1323
ENSG00000231135.9
22
iEKPD-Hos-1324
ENSG00000206481.11