※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ict-0645	ENSSTOG00000002413.3	I3M0D7	BARD1
2		iEKPD-Ict-0647	ENSSTOG00000000494.3	I3LWR9	Brca1
3		iEKPD-Ict-1257	ENSSTOG00000011752.3	I3MHY0	CTDP1
4		iEKPD-Ict-0646	ENSSTOG00000024303.2	I3NG11	LIG4
5		iEKPD-Ict-0644	ENSSTOG00000003089.3	I3M1N7	MCPH1
6		iEKPD-Ict-1264	ENSSTOG00000021788.2	I3MWX2	MDC1
7		iEKPD-Ict-1265	ENSSTOG00000015180.3	I3MPB1	NBN
8		iEKPD-Ict-0651	ENSSTOG00000016000.3	I3MQR2	PARP1
9		iEKPD-Ict-0641	ENSSTOG00000021376.2	I3MUU7	Paxip1
10		iEKPD-Ict-0653	ENSSTOG00000013937.3	I3MLZ5	PES1
11		iEKPD-Ict-0652	ENSSTOG00000011485.3	I3MHE8	POLL
12		iEKPD-Ict-0650	ENSSTOG00000014323.3	I3MMR4	REV1
13		iEKPD-Ict-0649	ENSSTOG00000007088.3	I3M945	RFC1
14		iEKPD-Ict-0648	ENSSTOG00000014040.3	I3MM70	SLF1
15		iEKPD-Ict-0640	ENSSTOG00000030500.1	A0A287D366	TOPBP1
16		iEKPD-Ict-0642	ENSSTOG00000006966.3	I3M8Y1	TP53BP1
17		iEKPD-Ict-0643	ENSSTOG00000019809.2	I3MTH7	XRCC1