※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (11) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Kop-0148	PAS_chr4_0716	C4R8Q2	NOP7; PAS_chr4_0716
2		iEKPD-Kop-0152	PAS_chr1-4_0269	C4QXY0	PAS_chr1-4_0269
3		iEKPD-Kop-0151	PAS_chr2-1_0444	C4R0P7	PAS_chr2-1_0444
4		iEKPD-Kop-0143	PAS_chr2-1_0643	C4R1B3	PAS_chr2-1_0643
5		iEKPD-Kop-0147	PAS_chr2-1_0768	C4R1P8	PAS_chr2-1_0768
6		iEKPD-Kop-0255	PAS_chr2-1_0845	C4R0N6	PAS_chr2-1_0845
7		iEKPD-Kop-0145	PAS_chr3_0395	C4R4F6	PAS_chr3_0395
8		iEKPD-Kop-0146	PAS_chr3_0732	C4R5E5	PAS_chr3_0732
9		iEKPD-Kop-0149	PAS_chr3_0797	C4R5L5	PAS_chr3_0797
10		iEKPD-Kop-0150	PAS_chr4_0675	C4R8K9	PAS_chr4_0675
11		iEKPD-Kop-0144	PAS_chr4_0903	C4R998	PAS_chr4_0903