※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (13) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Lem-0191	LEMA_P003140.1	E5AE88	LEMA_P003140.1
2		iEKPD-Lem-0317	LEMA_P007290.1	E5AFF3	LEMA_P007290.1
3		iEKPD-Lem-0197	LEMA_P008200.1	E5AFP4	LEMA_P008200.1
4		iEKPD-Lem-0193	LEMA_P039180.1	E4ZNF8	LEMA_P039180.1
5		iEKPD-Lem-0198	LEMA_P040370.1	E4ZPB1	LEMA_P040370.1
6		iEKPD-Lem-0189	LEMA_P055310.1	E4ZLZ5	LEMA_P055310.1
7		iEKPD-Lem-0195	LEMA_P079680.1	E5A531	LEMA_P079680.1
8		iEKPD-Lem-0190	LEMA_P079920.1	E5A555	LEMA_P079920.1
9		iEKPD-Lem-0192	LEMA_P080870.1	E5A5F0	LEMA_P080870.1
10		iEKPD-Lem-0194	LEMA_P088290.1	E5A7J5	LEMA_P088290.1
11		iEKPD-Lem-0188	LEMA_P109170.1	E4ZZ57	LEMA_P109170.1
12		iEKPD-Lem-0196	LEMA_P118590.1	E4ZTK0	LEMA_P118590.1
13		iEKPD-Lem-0318	LEMA_P120280.1	E4ZSU9	LEMA_P120280.1