※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mao-0181	MGG_02799	G5EGZ1	MGCH7_ch7g552; MGG_02799
2		iEKPD-Mao-0182	MGG_00485	G4NBT5	MGG_00485
3		iEKPD-Mao-0183	MGG_00691	G4NAX2	MGG_00691
4		iEKPD-Mao-0184	MGG_00809	G4NEA8	MGG_00809
5		iEKPD-Mao-0177	MGG_01032	G4NCT3	MGG_01032
6		iEKPD-Mao-0185	MGG_03204	G4NAB5	MGG_03204
7		iEKPD-Mao-0307	MGG_03485	G4N817	MGG_03485
8		iEKPD-Mao-0176	MGG_05040	G4N3W8	MGG_05040
9		iEKPD-Mao-0186	MGG_06436	G4N7A4	MGG_06436
10		iEKPD-Mao-0179	MGG_08613	G4ML01	MGG_08613
11		iEKPD-Mao-0178	MGG_12276	G4MYA2	MGG_12276
12		iEKPD-Mao-0180	MGG_12899	G4N5E4	MGG_12899