※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Map-0185	MAPG_00646	A0A0C4DLK2	MAPG_00646
2		iEKPD-Map-0181	MAPG_02239	A0A0C4DQU2	MAPG_02239
3		iEKPD-Map-0299	MAPG_03694	A0A0C4DUQ2	MAPG_03694
4		iEKPD-Map-0179	MAPG_05814	A0A0C4E0E1	MAPG_05814
5		iEKPD-Map-0184	MAPG_06634	A0A0C4E2J6	MAPG_06634
6		iEKPD-Map-0186	MAPG_07008	A0A0C4E3K5	MAPG_07008
7		iEKPD-Map-0183	MAPG_07549	A0A0C4E4Z2	MAPG_07549
8		iEKPD-Map-0182	MAPG_08058	A0A0C4E6C4	MAPG_08058
9		iEKPD-Map-0180	MAPG_08063	A0A0C4E6C9	MAPG_08063
10		iEKPD-Map-0176	MAPG_08201	A0A0C4E6Q5	MAPG_08201
11		iEKPD-Map-0178	MAPG_09880	A0A0C4EB36	MAPG_09880
12		iEKPD-Map-0177	MAPG_11238	A0A0C4EER1	MAPG_11238