※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (16) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mim-0653	ENSMICG00000014321.3
2		iEKPD-Mim-0654	ENSMICG00000010077.3
3		iEKPD-Mim-0655	ENSMICG00000014662.3
4		iEKPD-Mim-0656	ENSMICG00000038616.2
5		iEKPD-Mim-0657	ENSMICG00000014488.3
6		iEKPD-Mim-0659	ENSMICG00000028028.2
7		iEKPD-Mim-0660	ENSMICG00000001017.3
8		iEKPD-Mim-1292	ENSMICG00000038031.2
9		iEKPD-Mim-1294	ENSMICG00000010449.3
10		iEKPD-Mim-0661	ENSMICG00000016765.3
11		iEKPD-Mim-0662	ENSMICG00000015977.3
12		iEKPD-Mim-0663	ENSMICG00000017076.3
13		iEKPD-Mim-0665	ENSMICG00000006814.3
14		iEKPD-Mim-0666	ENSMICG00000010123.3
15		iEKPD-Mim-0658	ENSMICG00000043973.1	G5CWM2	BRCA1
16		iEKPD-Mim-0664	ENSMICG00000044578.1	A4PCE2	DNTT