Neurospora crassa      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 14 genes.  Reviewed (1 or Unreviewed (13

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Nec-0170
NCU06264
Q7SB49
mus-53; lig4; NCU06264
2
iEKPD-Nec-0174
NCU02053
Q7SDE5
mus-42; NCU02053
3
iEKPD-Nec-0173
NCU00185
Q7RXA2
NCU00185
4
iEKPD-Nec-0178
NCU02068
V5INV9
NCU02068
5
iEKPD-Nec-0168
NCU03924
Q1K5Z2
NCU03924
6
iEKPD-Nec-0177
NCU04079
Q7RWN0
NCU04079
7
iEKPD-Nec-0292
NCU06049
Q7S501
NCU06049
8
iEKPD-Nec-0176
NCU06767
Q7SCC0
NCU06767
9
iEKPD-Nec-0171
NCU07435
Q7SF18
NCU07435
10
iEKPD-Nec-0169
NCU08879
Q7S757
NCU08879
11
iEKPD-Nec-0291
NCU09300
V5IL65
NCU09300
12
iEKPD-Nec-0167
NCU09503
Q7S1G8
NCU09503
13
iEKPD-Nec-0175
NCU10417
V5ILR2
NCU10417
14
iEKPD-Nec-0172
NCU08852
Q7S7M3
parp; NCU08852