※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (16) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Prc-0595	ENSPCAG00000002269.1
2		iEKPD-Prc-0596	ENSPCAG00000012063.1
3		iEKPD-Prc-0597	ENSPCAG00000010574.1
4		iEKPD-Prc-0598	ENSPCAG00000003792.1
5		iEKPD-Prc-1111	ENSPCAG00000017043.1
6		iEKPD-Prc-0599	ENSPCAG00000015531.1
7		iEKPD-Prc-0600	ENSPCAG00000013385.1	Q9BDU1
8		iEKPD-Prc-0601	ENSPCAG00000014018.1
9		iEKPD-Prc-0602	ENSPCAG00000003540.1
10		iEKPD-Prc-0603	ENSPCAG00000015190.1
11		iEKPD-Prc-1112	ENSPCAG00000016950.1
12		iEKPD-Prc-0604	ENSPCAG00000012348.1
13		iEKPD-Prc-0605	ENSPCAG00000003954.1
14		iEKPD-Prc-0606	ENSPCAG00000004785.1
15		iEKPD-Prc-0607	ENSPCAG00000002413.1
16		iEKPD-Prc-0608	ENSPCAG00000010703.1