※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (10) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pug-0216	PGTG_06647	E3K873	NOP7; PGTG_06647
2		iEKPD-Pug-0215	PGTG_03464	E3JZN3	PGTG_03464
3		iEKPD-Pug-0213	PGTG_05872	E3K5Y0	PGTG_05872
4		iEKPD-Pug-0210	PGTG_09057	E3KFP0	PGTG_09057
5		iEKPD-Pug-0217	PGTG_09311	E3KH23	PGTG_09311
6		iEKPD-Pug-0214	PGTG_10537	E3KIN4	PGTG_10537
7		iEKPD-Pug-0212	PGTG_17985	E3L6Y6	PGTG_17985
8		iEKPD-Pug-0219	PGTG_19248	E3LA86	PGTG_19248
9		iEKPD-Pug-0211	PGTG_21909	H6QT04	PGTG_21909
10		iEKPD-Pug-0218	PGTG_22494	H6QUN0	PGTG_22494