※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Pyt-0185	PTRG_00349	B2VS10	PTRG_00349
2		iEKPD-Pyt-0178	PTRG_00947	B2VU23	PTRG_00947
3		iEKPD-Pyt-0181	PTRG_05684	B2W796	PTRG_05684
4		iEKPD-Pyt-0177	PTRG_05834	B2W7P6	PTRG_05834
5		iEKPD-Pyt-0186	PTRG_07010	B2WBJ7	PTRG_07010
6		iEKPD-Pyt-0317	PTRG_07427	B2WAW4	PTRG_07427
7		iEKPD-Pyt-0184	PTRG_09853	B2WIP4	PTRG_09853
8		iEKPD-Pyt-0179	PTRG_09982	B2WJ23	PTRG_09982
9		iEKPD-Pyt-0182	PTRG_10052	B2WJ93	PTRG_10052
10		iEKPD-Pyt-0183	PTRG_10572	B2WKR2	PTRG_10572
11		iEKPD-Pyt-0180	PTRG_10964	B2WLV4	PTRG_10964
12		iEKPD-Pyt-0316	PTRG_11566	B2WNK6	PTRG_11566