Saccharomyces cerevisiae      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 8 genes.  Reviewed (8 or Unreviewed (0

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Sac-0173
YOR005C
Q08387
DNL4; LIG4; YOR005C; UND407; UNE452
2
iEKPD-Sac-0169
YJL090C
P47027
DPB11; YJL090C; J0918
3
iEKPD-Sac-0290
YMR277W
Q03254
FCP1; YMR277W; YM8021.03
4
iEKPD-Sac-0174
YGR103W
P53261
NOP7; RRP13; YPH1; YGR103W
5
iEKPD-Sac-0170
YDR217C
P14737
RAD9; YDR217C; YD9934.02C
6
iEKPD-Sac-0175
YNL216W
P11938
RAP1; GRF1; TUF1; YNL216W; N1310
7
iEKPD-Sac-0172
YOR346W
P12689
REV1; YOR346W; O6339
8
iEKPD-Sac-0171
YHR154W
P38850
RTT107; ESC4; YHR154W