Sarcophilus harrisii      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 18 genes.  Reviewed (0 or Unreviewed (18

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Sah-0613
ENSSHAG00000007650.1
G3W079
2
iEKPD-Sah-0615
ENSSHAG00000011578.1
G3WDP0
3
iEKPD-Sah-0616
ENSSHAG00000010051.1
G3W8E9
4
iEKPD-Sah-0623
ENSSHAG00000011367.1
G3WCZ0
5
iEKPD-Sah-0617
ENSSHAG00000012998.1
G3WII6
BARD1
6
iEKPD-Sah-1198
ENSSHAG00000012579.1
G3WH29
CTDP1
7
iEKPD-Sah-0612
ENSSHAG00000010171.1
G3W8U5
ECT2
8
iEKPD-Sah-0622
ENSSHAG00000006134.1
G3VV55
LIG3
9
iEKPD-Sah-0614
ENSSHAG00000009525.1
G3W6K3
LIG4
10
iEKPD-Sah-0608
ENSSHAG00000011795.1
G3WEE0
LOC100913881
11
iEKPD-Sah-1206
ENSSHAG00000001663.1
G3VFB2
NBN
12
iEKPD-Sah-0620
ENSSHAG00000001991.1
G3VGD6
PARP1
13
iEKPD-Sah-0609
ENSSHAG00000010983.1
G3WBN3
PAXIP1
14
iEKPD-Sah-0621
ENSSHAG00000010289.1
G3W992
POLL
15
iEKPD-Sah-0619
ENSSHAG00000010618.1
G3WAE1
REV1
16
iEKPD-Sah-0618
ENSSHAG00000005764.1
G3VTW5
RFC1
17
iEKPD-Sah-0610
ENSSHAG00000013019.1
G3WIL4
TP53BP1
18
iEKPD-Sah-0611
ENSSHAG00000003185.1
G3VKC0
XRCC1