※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (12) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Scc-0165	SPOG_00661	S9XAL6	SPOG_00661
2		iEKPD-Scc-0173	SPOG_00854	S9VRP7	SPOG_00854
3		iEKPD-Scc-0174	SPOG_01048	S9X005	SPOG_01048
4		iEKPD-Scc-0302	SPOG_01784	S9W3E1	SPOG_01784
5		iEKPD-Scc-0166	SPOG_02267	S9VT84	SPOG_02267
6		iEKPD-Scc-0175	SPOG_02784	S9W606	SPOG_02784
7		iEKPD-Scc-0172	SPOG_03133	S9W138	SPOG_03133
8		iEKPD-Scc-0167	SPOG_03375	S9X840	SPOG_03375
9		iEKPD-Scc-0169	SPOG_03800	S9W5L2	SPOG_03800
10		iEKPD-Scc-0168	SPOG_04594	S9W4T2	SPOG_04594
11		iEKPD-Scc-0171	SPOG_04637	S9X747	SPOG_04637
12		iEKPD-Scc-0170	SPOG_04812	S9W116	SPOG_04812