※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982

  Reviewed (0)  or Unreviewed (15) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Tub-0543	ENSTBEG00000017345.1
2		iEKPD-Tub-0544	ENSTBEG00000015534.1
3		iEKPD-Tub-0545	ENSTBEG00000010870.1
4		iEKPD-Tub-0546	ENSTBEG00000006131.1
5		iEKPD-Tub-0547	ENSTBEG00000015473.1
6		iEKPD-Tub-0548	ENSTBEG00000012696.1
7		iEKPD-Tub-0549	ENSTBEG00000017741.1
8		iEKPD-Tub-0550	ENSTBEG00000016214.1
9		iEKPD-Tub-0551	ENSTBEG00000009460.1
10		iEKPD-Tub-0978	ENSTBEG00000013614.1
11		iEKPD-Tub-0552	ENSTBEG00000003087.1
12		iEKPD-Tub-0553	ENSTBEG00000012001.1
13		iEKPD-Tub-0554	ENSTBEG00000001150.1
14		iEKPD-Tub-0556	ENSTBEG00000002497.1
15		iEKPD-Tub-0555	ENSTBEG00000012984.1	A0A1B4Z9N5	BRCA1