Xenopus tropicalis      (pS/pT)/BRCT


※ BRCT family introduction

    BRCA1 C-terminal (BRCT) domain was originally discovered as a domain conserved in multiple DNA damage-response proteins. Named after one of the founding members, BRCA1, BRCT domains are often found as tandem repeats within a single protein. BRCA1, 53BP1, DNA LIgase IV, and MDC1, for example, contain 2 BRCT domains, while MCPH1 contains 3, Pax-2 interacting protein (PTIP) contains 6, and TopBP1 contains 8. There are approximately thirty BRCT domain-containing proteins in mammalian cells, and essentially all of these appear to have roles in DNA damage signaling and DNA repair. It must be noted, however, that not all BRCT domains function as phosphopeptide binding modules (1).

Reference
1. Mohammad, D.H. (2009) 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response . DNA Repair, 8, 1009-17. PMID: 19481982


There are 19 genes.  Reviewed (0 or Unreviewed (19

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Xet-0806
ENSXETG00000032616.1
F6Q591
2
iEKPD-Xet-0812
ENSXETG00000002639.3
F6TEQ8
3
iEKPD-Xet-0818
ENSXETG00000033465.1
F6QYW4
4
iEKPD-Xet-0809
ENSXETG00000014241.3
F6WNL0
bard1
5
iEKPD-Xet-0811
ENSXETG00000024564.2
F6TA60
brca1
6
iEKPD-Xet-1404
ENSXETG00000000856.3
F7B1B3
ctdp1
7
iEKPD-Xet-0807
ENSXETG00000023596.3
F6ZEX5
ect2
8
iEKPD-Xet-0810
ENSXETG00000002654.3
F6SN56
lig4
9
iEKPD-Xet-0816
ENSXETG00000015950.3
F6ZKZ2
mcph1
10
iEKPD-Xet-1415
ENSXETG00000014611.3
F7C3F8
nbn
11
iEKPD-Xet-0819
ENSXETG00000022610.3
F6X747
parp1
12
iEKPD-Xet-0805
ENSXETG00000006582.4
F6ZA69
paxip1
13
iEKPD-Xet-0820
ENSXETG00000030097.1
F6Y1Q9
PES1
14
iEKPD-Xet-0815
ENSXETG00000032755.1
F6Q4I4
poll
15
iEKPD-Xet-0814
ENSXETG00000019375.3
F7AWG2
rev1
16
iEKPD-Xet-0817
ENSXETG00000012866.3
F7C9M5
rfc1
17
iEKPD-Xet-0813
ENSXETG00000013387.3
F6V0Z8
slf1
18
iEKPD-Xet-0804
ENSXETG00000001854.3
F6XFW7
topbp1
19
iEKPD-Xet-0808
ENSXETG00000015128.3
F6TC23
xrcc1