※ GK family introduction

    Membrane-associated guanylate kinases (MAGUKs) are a kind of scaffold proteins that play essential roles in tissue developments, cell–cell communications, cell polarity control, and cellular signal transductions. Despite extensive studies over the past two decades, the functions of the signature guanylate kinase domain (GK) of MAGUKs are poorly understood. However, recent study shows that the GK domain of DLG1/SAP97 binds to asymmetric cell division regulatory protein LGN in a phosphorylation-dependent manner (1).

Reference
1. Zhu, J. (2011) Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-bindingmodules. EMBO J, 30, 4986-97. PMID: 22117215

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Cas-1246	ENSTSYG00000014126.2	A0A1U7UQ46	DLG1
2		iEKPD-Cas-1247	ENSTSYG00000009652.2	A0A1U7U856	DLG2
3		iEKPD-Cas-1248	ENSTSYG00000012919.2	A0A1U7TMR9	DLG4