Homo sapiens      (pS/pT)/PBD


※ PBD family introduction

    C-terminal Polo-box domains (PBDs) of Plks, acting as pS/pT-binding modules, are crucial for orchestrating the proper sub-cellular localizations and kinase activities of Plks during multiple stages of mitosis. Moreover, Plk-mediated phosphoregulation can regulate a variety of biological and cellular processes beyond mitosis, such as DNA damage, centriole duplication, transcription regulation and stress-activated MAPK cascade (1).

Reference
1. Liu, Z. (2013) Systematic analysis of the Plk-mediated phosphoregulation in eukaryotes . Brief Bioinform, 14, 344-60. PMID: 22851512


There are 3 genes.  Reviewed (3 or Unreviewed (0

No.StatusiEKPD IDEnsemble Gene IDUniProt AccessionGene Name
1
iEKPD-Hos-1301
ENSG00000166851.14
P53350
PLK1; PLK
2
iEKPD-Hos-1294
ENSG00000145632.14
Q9NYY3
PLK2; SNK
3
iEKPD-Hos-1302
ENSG00000173846.12
Q9H4B4
PLK3; CNK; FNK; PRK