※ PDZ family introduction

    The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. These domains play a key role in the formation and function of signal transduction complexes. The PDZ domain of RGS3 were found to bind to the Tyr304 phosphopeptide of ephrin B2 in recent study (1).

Reference
1. Su, Z. (2011) Single phosphorylation of Tyr304 in the cytoplasmic tail of ephrin B2 confers high-affinity and bifunctional binding to both the SH2 domain of Grb4 and the PDZ domain of the PDZ-RGS3 protein. Eur J Biochem, 271, 1725-36. PMID: 15096211

  Reviewed (2)  or Unreviewed (113) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0843	ENSSSCG00000015796.3	Q6QGC0	PDLIM3
2		iEKPD-Sus-0808	ENSSSCG00000012378.4	Q6QA76	PDZD11; PDZK11
3		iEKPD-Sus-0795	ENSSSCG00000010559.2	F1S8U5
4		iEKPD-Sus-0810	ENSSSCG00000003793.3	F1S832
5		iEKPD-Sus-0811	ENSSSCG00000005480.3	F1SN86
6		iEKPD-Sus-0824	ENSSSCG00000014186.3	A0A287BE79
7		iEKPD-Sus-0837	ENSSSCG00000025557.2	I3LKM3
8		iEKPD-Sus-0846	ENSSSCG00000010359.3	F1SEN8
9		iEKPD-Sus-0855	ENSSSCG00000012253.4	K7GSB2
10		iEKPD-Sus-0856	ENSSSCG00000033829.1	A0A287AJI0
11		iEKPD-Sus-1311	ENSSSCG00000015401.3	F1SBX0
12		iEKPD-Sus-0865	ENSSSCG00000036669.1	A0A286ZN89
13		iEKPD-Sus-0809	ENSSSCG00000004018.3	A0A286ZM64	AFDN
14		iEKPD-Sus-1327	ENSSSCG00000005250.3	F1SJD2	APBA1
15		iEKPD-Sus-1328	ENSSSCG00000013492.3	A0A287BC13	APBA3
16		iEKPD-Sus-0841	ENSSSCG00000011074.3	I3LTT6	ARHGAP21
17		iEKPD-Sus-0825	ENSSSCG00000018058.3	A0A287A5N4	ARHGAP23
18		iEKPD-Sus-0826	ENSSSCG00000006461.3	F1RHK9	ARHGEF11
19		iEKPD-Sus-0819	ENSSSCG00000015129.3	A0A287AV56	ARHGEF12
20		iEKPD-Sus-0861	ENSSSCG00000012164.3	A0A287AJ55	CNKSR2
21		iEKPD-Sus-0864	ENSSSCG00000004071.3	F1SB22	CNKSR3
22		iEKPD-Sus-0815	ENSSSCG00000029753.2	A0A287B989	CYTIP
23		iEKPD-Sus-1321	ENSSSCG00000011833.4	A0A287BTJ2	DLG1
24		iEKPD-Sus-1322	ENSSSCG00000014904.3	F1STU6	DLG2
25		iEKPD-Sus-0779	ENSSSCG00000012375.3	F1RTL4	DLG3
26		iEKPD-Sus-0780	ENSSSCG00000024285.2	I3LMS7	DLG4
27		iEKPD-Sus-0787	ENSSSCG00000026268.3	I3LBQ4	DLG5
28		iEKPD-Sus-0835	ENSSSCG00000003342.3	F1RJE5	DVL1
29		iEKPD-Sus-0831	ENSSSCG00000025689.2	A0A287AJQ6	DVL2
30		iEKPD-Sus-0829	ENSSSCG00000025374.2	A0A287AAL7	DVL3
31		iEKPD-Sus-0802	ENSSSCG00000016954.4	A0A287AVI3	ERBIN
32		iEKPD-Sus-0849	ENSSSCG00000005352.3	F1ST70	FRMPD1
33		iEKPD-Sus-0784	ENSSSCG00000010379.3	F1SEL2	FRMPD2
34		iEKPD-Sus-0854	ENSSSCG00000012561.3	A0A287BLT9	FRMPD3
35		iEKPD-Sus-0860	ENSSSCG00000030877.2	A0A287BQD7	FRMPD4
36		iEKPD-Sus-0806	ENSSSCG00000004253.2	A0A287A6H2	GOPC
37		iEKPD-Sus-0847	ENSSSCG00000034916.1	A0A287B4K8	GORASP1
38		iEKPD-Sus-0853	ENSSSCG00000015943.3	F1S1U5	GORASP2
39		iEKPD-Sus-0820	ENSSSCG00000000234.3	F1SGJ8	GRASP
40		iEKPD-Sus-0797	ENSSSCG00000037070.1	A0A287AGA1	GRID2IP
41		iEKPD-Sus-0772	ENSSSCG00000000478.4	F1SH70	GRIP1
42		iEKPD-Sus-0773	ENSSSCG00000011599.3	A0A286ZTP0	GRIP2
43		iEKPD-Sus-0778	ENSSSCG00000001787.4	A0A288CFU1	IL16
44		iEKPD-Sus-0800	ENSSSCG00000040348.1	A0A287ADP5	LIN7A
45		iEKPD-Sus-0799	ENSSSCG00000003157.3	F1RIN6	LIN7B
46		iEKPD-Sus-0798	ENSSSCG00000022806.2	A0A287AKE5	LIN7C
47		iEKPD-Sus-0776	ENSSSCG00000008838.3	A0A287BIK0	LNX1
48		iEKPD-Sus-0782	ENSSSCG00000009308.3	F1RSW8	LNX2
49		iEKPD-Sus-1324	ENSSSCG00000011497.3	A0A287B5P8	MAGI1
50		iEKPD-Sus-1326	ENSSSCG00000031780.1	A0A287AC12	MAGI2
51		iEKPD-Sus-1325	ENSSSCG00000006767.3	A0A287AK47	MAGI3
52		iEKPD-Sus-0816	ENSSSCG00000012295.4	F1RW42	MAGIX
53		iEKPD-Sus-1280	ENSSSCG00000013732.3	F1SDY2	MAST1
54		iEKPD-Sus-1263	ENSSSCG00000003913.3	F1S3V0	MAST2
55		iEKPD-Sus-1282	ENSSSCG00000013895.3	A0A286ZV64	MAST3
56		iEKPD-Sus-1284	ENSSSCG00000016956.3	A0A287B3A0	MAST4
57		iEKPD-Sus-0770	ENSSSCG00000005191.3	F1SMP5	MPDZ
58		iEKPD-Sus-0852	ENSSSCG00000012822.4	K7GP41	MPP1
59		iEKPD-Sus-0836	ENSSSCG00000017372.3	F1S1I8	MPP3
60		iEKPD-Sus-0862	ENSSSCG00000026184.2	I3LC30	MPP4
61		iEKPD-Sus-0839	ENSSSCG00000002287.3	F1SA41	MPP5
62		iEKPD-Sus-0827	ENSSSCG00000011070.3	A0A287B6J9	MPP7
63		iEKPD-Sus-0840	ENSSSCG00000009856.3	A0A287BKF3	NOS1
64		iEKPD-Sus-0792	ENSSSCG00000011103.3	F1RUR8	PARD3
65		iEKPD-Sus-0793	ENSSSCG00000016123.3	F1SHE2	PARD3B
66		iEKPD-Sus-0834	ENSSSCG00000034863.1	A0A286ZZ01	PARD6A
67		iEKPD-Sus-0842	ENSSSCG00000027206.3	A0A286ZXK0	PARD6B
68		iEKPD-Sus-0851	ENSSSCG00000023376.2	I3LSR2	PARD6G
69		iEKPD-Sus-0771	ENSSSCG00000039793.1	A0A287AG82	PATJ
70		iEKPD-Sus-0832	ENSSSCG00000010493.3	F1SC51	PDLIM1
71		iEKPD-Sus-0838	ENSSSCG00000009625.3	F1RMA7	PDLIM2
72		iEKPD-Sus-0857	ENSSSCG00000014274.3	F1RJV5	PDLIM4
73		iEKPD-Sus-0863	ENSSSCG00000009192.3	A0A287A3D2	PDLIM5
74		iEKPD-Sus-0859	ENSSSCG00000040507.1	A0A287BEH6	PDLIM7
75		iEKPD-Sus-0774	ENSSSCG00000016810.3	F1SP36	PDZD2
76		iEKPD-Sus-0781	ENSSSCG00000027710.2	A0A287BMC0	PDZD3
77		iEKPD-Sus-0822	ENSSSCG00000012785.4	K7GRK2	PDZD4
78		iEKPD-Sus-0775	ENSSSCG00000006693.3	I3LJJ8	PDZK1
79		iEKPD-Sus-0813	ENSSSCG00000011521.3	F1SFM6	PDZRN3
80		iEKPD-Sus-0812	ENSSSCG00000000791.3	F1SH06	PDZRN4
81		iEKPD-Sus-0804	ENSSSCG00000000114.3	A0A287BKT1	PICK1
82		iEKPD-Sus-0817	ENSSSCG00000015329.3	A0A287B2F8	PPP1R9A
83		iEKPD-Sus-0818	ENSSSCG00000017584.4	F1RT57	PPP1R9B
84		iEKPD-Sus-0850	ENSSSCG00000031118.1	A0A286ZUE0	PREX1
85		iEKPD-Sus-0823	ENSSSCG00000006199.3	A0A286ZSP2	PREX2
86		iEKPD-Sus-1306	ENSSSCG00000026655.2	I3LMD8	PTPN13
87		iEKPD-Sus-1305	ENSSSCG00000005449.3	F1SP08	PTPN3
88		iEKPD-Sus-1300	ENSSSCG00000015743.3	F1RXW4	PTPN4
89		iEKPD-Sus-0845	ENSSSCG00000007575.3	F1RI52	RADIL
90		iEKPD-Sus-0833	ENSSSCG00000008881.3	A0A287A643	RAPGEF2
91		iEKPD-Sus-0828	ENSSSCG00000014267.3	A0A287BCN3	RAPGEF6
92		iEKPD-Sus-1329	ENSSSCG00000008698.3	F1S8N3	RGS12
93		iEKPD-Sus-0830	ENSSSCG00000006957.3	F1SEV5	RHPN1
94		iEKPD-Sus-1312	ENSSSCG00000004280.3	F1RTS7	RIMS1
95		iEKPD-Sus-1323	ENSSSCG00000039466.1	A0A287AKT5	SCRIB
96		iEKPD-Sus-0794	ENSSSCG00000007189.3	F1S878	SDCBP2
97		iEKPD-Sus-0789	ENSSSCG00000006237.3	A0A286ZKH9	SDCBP
98		iEKPD-Sus-0858	ENSSSCG00000031925.1	A0A287BEU5	SHANK3
99		iEKPD-Sus-0848	ENSSSCG00000012104.4	K7GQZ0	SHROOM2
100		iEKPD-Sus-0788	ENSSSCG00000017232.3	B8XH67	SLC9A3R1
101		iEKPD-Sus-0791	ENSSSCG00000008038.3	B6EAV5	SLC9A3R2
102		iEKPD-Sus-0796	ENSSSCG00000007264.3	A0A287B2G7	SNTA1
103		iEKPD-Sus-0803	ENSSSCG00000005994.3	F1S288	SNTB1
104		iEKPD-Sus-0805	ENSSSCG00000028109.2	I3LDU9	SNTB2
105		iEKPD-Sus-0801	ENSSSCG00000034495.1	A0A287ADJ3	SNTG1
106		iEKPD-Sus-0821	ENSSSCG00000006619.3	F1ST14	SNX27
107		iEKPD-Sus-1330	ENSSSCG00000017602.3	F1RSF7	STXBP4
108		iEKPD-Sus-0807	ENSSSCG00000026389.2	F1S4A6	SYNJ2BP
109		iEKPD-Sus-0844	ENSSSCG00000009111.3	A0A287AUH9	SYNPO2
110		iEKPD-Sus-0814	ENSSSCG00000017866.2	F2Z516	TAX1BP3
111		iEKPD-Sus-0777	ENSSSCG00000004854.3	A0A287BF71	TJP1
112		iEKPD-Sus-0786	ENSSSCG00000005247.3	A0A287AZ07	TJP2
113		iEKPD-Sus-0785	ENSSSCG00000013491.3	F1S7Q6	TJP3
114		iEKPD-Sus-0790	ENSSSCG00000013377.3	F1S9A7	USH1C
115		iEKPD-Sus-0783	ENSSSCG00000005490.3	A0A286ZPD1	WHRN