Ailuropoda melanoleuca (pS/pT)/WD40
※ WD40 family introduction WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. A widespread protein-interaction domain, of which some members (bTRCP and CDC4) bind specifically to pSer or pThr motifs. Many or most are probably not phospho-specific (1). Reference
1. http://www.ebi.ac.uk/interpro/entry/IPR001680
There are 248 genes. Reviewed (0)
or Unreviewed (248) 
※ WD40 family introduction WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. A widespread protein-interaction domain, of which some members (bTRCP and CDC4) bind specifically to pSer or pThr motifs. Many or most are probably not phospho-specific (1). Reference
1. http://www.ebi.ac.uk/interpro/entry/IPR001680
There are 248 genes. Reviewed (0)
or Unreviewed (248)