※ C2 family introduction

    A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 beta-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. The C2 domain of PRKCQ, the closest relative of PRKCQ in the PKC family, was found to be a novel Tyr(P)-binding domain, which could specifically bind a Tyr(P)-containing peptide derived from CDCP1, a protein known to be phosphorylated on tyrosine by activated Src kinase (1).

Reference
1. Stahelin, R.V. (2012) PRKCQ C2 domain is a phosphotyrosine binding module that plays a key role in its activation . J Biol Chem, 287, 30518-28. PMID: 22787157

  Reviewed (0)  or Unreviewed (7) 

No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Mae-1748	MANES_01G259100	A0A2C9WPL4	MANES_01G259100
2		iEKPD-Mae-1746	MANES_02G196900	A0A2C9WFJ0	MANES_02G196900
3		iEKPD-Mae-1747	MANES_05G036600	A0A2C9VSZ9	MANES_05G036600
4		iEKPD-Mae-1751	MANES_05G145400	A0A2C9VW90	MANES_05G145400
5		iEKPD-Mae-1749	MANES_10G148000	A0A2C9V668	MANES_10G148000
6		iEKPD-Mae-1750	MANES_14G117400	A0A2C9ULY8	MANES_14G117400
7		iEKPD-Mae-1745	MANES_18G104300	A0A2C9U2B6	MANES_18G104300