※ C2 family introduction

    A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 beta-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. The C2 domain of PRKCQ, the closest relative of PRKCQ in the PKC family, was found to be a novel Tyr(P)-binding domain, which could specifically bind a Tyr(P)-containing peptide derived from CDCP1, a protein known to be phosphorylated on tyrosine by activated Src kinase (1).

Reference
1. Stahelin, R.V. (2012) PRKCQ C2 domain is a phosphotyrosine binding module that plays a key role in its activation . J Biol Chem, 287, 30518-28. PMID: 22787157

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Ora-0669	ENSOANG00000002710.4	F6UB92
2		iEKPD-Ora-0672	ENSOANG00000011064.2	F7FKM6
3		iEKPD-Ora-0676	ENSOANG00000013071.3	F6ZB17
4		iEKPD-Ora-0677	ENSOANG00000003231.1	F6THJ1
5		iEKPD-Ora-0678	ENSOANG00000005810.2	F7CKY5
6		iEKPD-Ora-0668	ENSOANG00000010036.2	F6W9Y7	DOC2A
7		iEKPD-Ora-0670	ENSOANG00000021214.2	F7EHW0	LOC100091001
8		iEKPD-Ora-0673	ENSOANG00000013051.2	F7AV07	PCLO
9		iEKPD-Ora-1185	ENSOANG00000011330.3	F7GEP6	PLCG2
10		iEKPD-Ora-1175	ENSOANG00000015452.2	F6PVR3	PRKCQ
11		iEKPD-Ora-0666	ENSOANG00000000228.2	F7C0J1	RPH3A
12		iEKPD-Ora-0665	ENSOANG00000007531.3	F7CH73	SYT1
13		iEKPD-Ora-0667	ENSOANG00000002513.4	F6UHG7	SYT2
14		iEKPD-Ora-0671	ENSOANG00000002748.2	F6TDM4	SYT4
15		iEKPD-Ora-0674	ENSOANG00000013207.3	F7A0A7	SYTL2
16		iEKPD-Ora-0675	ENSOANG00000007114.2	F6QSA8	SYTL5