※ C2 family introduction

    A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 beta-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. The C2 domain of PRKCQ, the closest relative of PRKCQ in the PKC family, was found to be a novel Tyr(P)-binding domain, which could specifically bind a Tyr(P)-containing peptide derived from CDCP1, a protein known to be phosphorylated on tyrosine by activated Src kinase (1).

Reference
1. Stahelin, R.V. (2012) PRKCQ C2 domain is a phosphotyrosine binding module that plays a key role in its activation . J Biol Chem, 287, 30518-28. PMID: 22787157

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No.	Status	iEKPD ID	Ensemble Gene ID	UniProt Accession	Gene Name
1		iEKPD-Sus-0695	ENSSSCG00000012895.3	A0A287ABZ3
2		iEKPD-Sus-1311	ENSSSCG00000015401.3	F1SBX0
3		iEKPD-Sus-0682	ENSSSCG00000034635.1	A0A287ASK3	DOC2A
4		iEKPD-Sus-0678	ENSSSCG00000039412.1	A0A287BHY3	DOC2B
5		iEKPD-Sus-0698	ENSSSCG00000008312.3	F1SLE7	DYSF
6		iEKPD-Sus-0693	ENSSSCG00000000379.3	A0A287ASV9	ESYT1
7		iEKPD-Sus-0692	ENSSSCG00000025286.2	A0A287ANJ5	MCTP1
8		iEKPD-Sus-0697	ENSSSCG00000010476.3	A0A287AHC3	MYOF
9		iEKPD-Sus-0701	ENSSSCG00000037751.1	A0A287BS85	OTOF
10		iEKPD-Sus-1313	ENSSSCG00000002688.3	F1S475	PLCG2
11		iEKPD-Sus-1287	ENSSSCG00000023503.2	A0A287A287	PRKCD
12		iEKPD-Sus-1277	ENSSSCG00000011131.3	A0A287AH32	PRKCQ
13		iEKPD-Sus-1314	ENSSSCG00000014146.3	A0A287A3J8	RASA1
14		iEKPD-Sus-0699	ENSSSCG00000027890.2	I3LAT0	RASA4B
15		iEKPD-Sus-1312	ENSSSCG00000004280.3	F1RTS7	RIMS1
16		iEKPD-Sus-0680	ENSSSCG00000009883.3	A0A287AX24	RPH3A
17		iEKPD-Sus-0687	ENSSSCG00000000527.3	F1SGD3	SYT10
18		iEKPD-Sus-0690	ENSSSCG00000006506.3	F1RLM5	SYT11
19		iEKPD-Sus-0694	ENSSSCG00000022200.2	A0A287B306	SYT17
20		iEKPD-Sus-0679	ENSSSCG00000000948.3	F1RYK1	SYT1
21		iEKPD-Sus-0681	ENSSSCG00000010926.3	F1S5A0	SYT2
22		iEKPD-Sus-0684	ENSSSCG00000003222.3	F1RH13	SYT3
23		iEKPD-Sus-0689	ENSSSCG00000037079.1	A0A287A0G7	SYT4
24		iEKPD-Sus-0683	ENSSSCG00000021843.2	A0A287BAW8	SYT5
25		iEKPD-Sus-0688	ENSSSCG00000006758.3	A0A287A9R7	SYT6
26		iEKPD-Sus-0685	ENSSSCG00000021906.2	A0A287AWQ2	SYT7
27		iEKPD-Sus-0686	ENSSSCG00000014599.3	F1RNF4	SYT9
28		iEKPD-Sus-0700	ENSSSCG00000003572.3	F1STQ1	SYTL1
29		iEKPD-Sus-0691	ENSSSCG00000012484.3	F1S1M2	SYTL4
30		iEKPD-Sus-0696	ENSSSCG00000012233.4	F1RXS2	SYTL5